If they have not unsubscribed, and you're not going directly to the spam folder, you still have a chance to convert them.
It is important to remember that even if your copy is perfect, and you've done it all right, some people will simply just stop opening your email for no reason whatsoever. There are reasons for this, sometimes it is that your email is disappearing into the spam black hole, and sometimes it's just that they weren't interested to start with. Perhaps they were a freebie seeker and really did only join to get the free eReports or eBook that you were offering. This happens, if you try to reengage them and it does not work, then it is time to delete them off your list.
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